OXA-72-producing Acinetobacter baumannii in Brazil: a case report.

by the integration of a partly truncated class 2 integron as well as the deletion of large parts of the mobA gene (including the mobB gene) and the tetracycline resistance gene tet(B). To the best of our knowledge, this is the first description of class 2-associated resistance gene cassettes in members of the genus Pasteurella. In contrast to P. multocida, which is found in the respiratory tract of various animal species, P. aerogenes is commonly found in the intestinal tract of swine, and may be associated with diarrhoea and other infections. 5 As such, it is in contact with Enterobacteriaceae, which frequently carry class 1 and class 2 integrons on plasmids. 9 Since plasmids from E. coli and other Enterobacteriaceae usually cannot replicate in Pasteu-rella hosts, recombination of a transferred enterobacterial plasmid with plasmids indigenous to Pasteurella ensures a stable maintenance of the newly acquired resistance genes in the Pasteurella host. The in-depth analysis of plasmid pCCK343 from P. aerogenes provides further support for such inter-and intra-plasmid recombination events. Moreover, the data presented in this study substantiate the assumption of a gene flux between Enterobacteriaceae and P. aerogenes, which has previously been suggested based on the finding that the tetracycline resistance gene tet(B)—the predominant tet gene among Enterobacteriaceae—is most frequently found in P. aerogenes.